Sitefinity websites can contain a large amount of JavaScript files, possibly up to a megabyte. Thus enabling HTTP compression can significantly increase the performance of your website.
YSlow stats of a Sitefinity page with a lot of JavaScript.
To enable HTTP compression first add this under system.webServer in the web.config
<urlCompression
doDynamicCompression="true"
dynamicCompressionBeforeCache="true" />
<httpCompression
cacheControlHeader="max-age=86400"
noCompressionForHttp10="false"
noCompressionForProxies="false"
sendCacheHeaders="true"
minFileSizeForComp="1" />
Then this in the ServiceDefinition.csdef file under the Webrole